
Join us for the annual symposium of the Austrian Proteomics and Metabolomics Association (APMA) in Innsbruck, Austria, in 2023. This symposium will gather researchers, scientists, and experts in the field of proteomics and metabolomics for an enriching exchange of ideas and collaborations. Stay connected for more information on a program filled with insightful lectures and poster presentations. Don’t miss this exceptional opportunity to connect with peers, gain valuable insights, to share ideas and be in touch with the APMA community. Save the date and be part of this exciting symposium in Innsbruck!
Venue
The conference will take place in the Center for Chemistry and Biomedicine (CCB) on Campus Innrain of the Leopold-Franzens-University Innsbruck.
Leopold-Franzens Universität Innsbruck
Centrum für Chemie und Biomedizin
Innrain 80-82
A-6020 Innsbruck
Registration & Abstract Submission
- Registration is open now!
- Free of charge for APMA members.
- Non-APMA members: 50 €
- Abstract submission deadline: 31.August 2023
- We highly encourage Master / PhD students and young researchers to submit.
- All selected contributions will be presented as oral presentations (10 minutes) or in a poster format
Confirmed Speakers
Professor Ole N. Jensen at SDU, Odense, Denmark studies proteins and proteomes to reveal regulatory features, focusing on post-translational modifications (PTMs). He uses mass spectrometry and ion mobility spectrometry to investigate histone proteins and their PTMs in the context of chromatin biology, epigenetics and cancer.
Frank Klont obtained his Pharmacy degree at the University of Groningen where he subsequently also conducted his PhD studies on targeted protein analysis under supervision of Prof. Rainer Bischoff. Next, he joined the Hopfgartner group at the University of Geneva where he gained experience in untargeted metabolomics, in particularly focusing on the identification of xenobiotics and the profiling of (real-world) drug metabolites in population-based studies. In 2022, he returned to Groningen to start as an assistant professor in personalized pharmacotherapy working both at the Groningen Research Institute of Groningen and the hospital pharmacy department of the University Medical Center Groningen. His position is aimed at the integration of a patient’s clinical profile, biomarker status, co-medication, genetic makeup, and (pharmaco)metabolomic profile with the goal to contribute to further personalization of drug treatments
Anneli Kruve graduated in 2011 from the University of Tartu and continued her studies as a post-doc in Technion, Israel. Anneli Kruve was a Humboldt fellow at Freie Universität Berlin (2017–2018). In 2019 Kruve joined Stockholm University and she is in charge of the mass spectrometry laboratory at Stockholm University. Anneli Kruve was selected in 2018 to be among the Top 40 under 40 power list by the Analytical Scientist. Her field of study is the fundamentals and applications of mass spectrometry. Specifically, her group uses modelling and machine learning to understand ionization processes in electrospray, unravel the quantification, structural assignment and toxicity assessment challenges in environmental non-targeted screening. Her group has developed machine learning models to predict the ionization efficiency of compounds in electrospray, which can be further used to quantify the contaminants detected with non-targeted LC/HRMS even if analytical standards are not available. Recently, her group has started exploring the possibility to use empirical analytical information to quantify and assess the toxicity of chemicals detected with mass spectrometry. The research group of Kruve is also investigating the structural characterization of small with high-resolution ion mobility.
Kathrin Breuker is an Associate Professor at the University of Innsbruck, Austria, where her research group uses a special type of mass spectrometer (FT-ICR MS, Fourier transform-ion cyclotron resonance mass spectrometer) for the study of larger biomolecules with focus on ribonucleic acids (RNA). The group is interested in the structure, folding, interactions, and reactivity of RNA in the gas and condensed phases, and develops new approaches for RNA characterization, including the localization of modification and binding sites.
Monika Cziferszky earned her PhD in polymer chemistry under Prof. Robert Liska from the Vienna University of Technology in 2008 before moving for a postdoctoral stay to the University of Cambridge to delve into supramolecular chemistry in the group of Prof. Oren Scherman. There, she developed a keen interest in using mass spectrometry to answer various research questions. Upon her return to Austria, she entered the field of bioinorganic chemistry during a postdoctoral stay with Prof. Ronald Gust at the University of Innsbruck. In 2019, she was appointed as an Assistant Professor at the University of Innsbruck. Lately, she has focused on using mass spectrometry to delineate the modes-of-action of metal-based drugs.
Markus A. Keller is an expert for lipid metabolism with a special focus on inborn metabolic diseases. He started to gain his expertise in his PhD where he dedicated his work to understand the molecular mechanisms of inherited metabolic disorders. At the University of Cambridge, he deepened his knowledge by investigating the enzymology and properties of the lipid metabolic network. Employing advanced LC-MS/MS techniques and bioinformatic strategies, he unravels complex regulatory mechanisms of lipid metabolism. Building upon his expertise, Markus A. Keller established a Biochemical Genetics research group at the Medical University of Innsbruck, where he also heads an ISO15189 accredited laboratory focusing on diagnosis and therapy monitoring of metabolic diseases.
Andreas Koeberle is the Head of the Michael Popp Institute and Full Professor at the University of Innsbruck. His research is located at the interface of inflammation, cancer, and metabolic disease and aims at setting the molecular foundation for the development of phytomedicine in interdisciplinary collaboration. Main areas of expertise are bioactive lipids, their biosynthesis and regulation, as well as strategies for therapeutic intervention. His group uses cutting-edge chromatographic and mass spectrometric methods for targeted lipid bioanalytics (lipidomics), which provides access to the manifold, widely unexplored interrelations between lipid metabolism and signal transduction.
Programm
Wednesday, 27.09.2023 |
|
8:30-9:00 |
Registration |
9:00-9:15 |
Welcome |
9:15-10:00 |
Native top-down mass
spectrometry for the study of ligand binding to RNA, Kathrin Breuker, University of Innsbruck |
Proteomics 1 |
|
10:00-10:20 |
Exploring Cell-to-Cell
Communications through Secretomics Analysis, Juan Manuel Sacnun, Medical University of Vienna |
10:20-10:40 |
Proteome analysis of
mouse retinas carrying pathogenic Cav1.4 L-type calcium channel variants, Matthias Ganglberger, University of Innsbruck |
10:40-11:00 |
Proteomic Insights into
Age and Sex Effects in Biomedical Studies, Feng Xian, University of
Vienna |
11:00-11:30 |
Coffee Break |
11:30-12:15 |
MS2Tox & MS2Quant:
Automated Prediction of Toxicity and Concentration of Chemicals in Complex
Mixtures, Anneli Kruve, Stockholm
University |
Young Scientist
Session |
|
12:15-12:35 |
Modular comparison of
untargeted metabolomics data processing steps, Markus Aigensberger, University of Natural Resources and Life Sciences |
12:35-12:55 |
Metabolism-related
effects of penitrem mycotoxins on HepG2 cells, Lucas Keuter,
University of Muenster |
12:55-13:15 |
Comparison of
chromatographic conditions for the targeted tandem mass spectrometric
determination of 354 mammalian metabolites, Kangkang Xu, University of Natural Resources and Life
Sciences |
13:15-14:45 |
Lunch |
14:45-15:15 |
Top-down and
energy-resolved mass spectrometry approaches in the development of
metal-based drugs, Monika Czifersky, University of Innsbruck |
Proteomics 2 |
|
15:15-15:35 |
Characterization of the
potential tumor suppressor BASP1, Leonie Weber, University
of Innsbruck |
15:35-15:55 |
The impact of the
expression of different HRAS variants on the proteome profile of human keratinocytes, Thomas Mair, University
Medical Center Hamburg-Eppendorf |
15:55-16:15 |
Deeper proteome coverage and faster throughput for low input samples on the Orbitrap Astral mass spectrometer, Andre Mueller, Thermo
Fisher Scientific |
16:15-18:00 |
Poster Session & Coffee |
18:00-21:00 |
Get Together |
Thursday, 28.09.2023 |
|
9:00-9:45 |
Proteoform characterization by mass spectrometry and ion mobility spectrom-etry of intact proteins, Ole Jensen, University of
Southern Denmark |
Proteomics 3 |
|
9:45-10:05 |
Systematic identification
of druggable PKA substrates involved in colon cancer progression, Valentina Kugler,
University of Innsbruck |
10:05-10:25 |
Deciphering the MuSK Signaling Network using Proximity-Dependent
Labeling, Cinzia Barresi, Medical University of Vienna |
10:25-10:45 |
The ProtiFi Omics Multiverse, John P Wilson, ProtiFi
|
10:45-11:15 |
Coffee Break |
11:15-12:00 |
Harnessing Lipidomics: Unveiling Innovative Biogenic Agents against
Cancer and Inflammation, Andreas Koeberle, University of Innsbruck |
Multi-Omics |
|
12:00-12:20 |
Multi-omics investigation
of central metabolism shifts in tuberous sclerosis complex, Anna-Sophia Egger, University
of Innsbruck |
12:20-12:40 |
Multi-Omics Data of
Perturbation Studies are Determined by Memory Effects from Subculture, Patricia Bortel, University of Vienna |
12:40-13:00 |
Linking acetyl-CoA
labelling and histone acetylation dynamics for accurate determination of
acetylation rates via ordinary differential equations, Eva Rauch, University of
Innsbruck |
13:20-14:30 |
Lunch |
14:30-15:15 |
Untargeted metabolomics
for studying drug exposure and real-world drug metabolism in population-based
studies, Frank Klont,
University of Groningen |
Metabolomics |
|
15:15-15:25 |
Development of an
automatized method for quantitative analysis of amino acids and tryptophan
metabolites from human serum and plasma, Tobias Kipura, University
of Innsbruck |
15:25-15:45 |
Plasma instead of serum
avoids critical confounding of clinical metabolomics studies by platelets, Gerhard Hagn, University of Vienna |
15:45-16:05 |
Performance Evaluation of
Untargeted Metabolomics Workflows, Christina Maisl, University of Natural Resources and Life Sciences |
16:05-17:30 |
Poster Session, Coffee |
17:30-18:30 |
General Assembly |
18:30 |
BBQ |
Friday, 30.09.2023 |
|
9:00-9:45 |
Solving Biochemical Riddles of Lipid Metabolism in Inherited Metabolic Dis-ease through Mass Spectrometry, Markus Keller, Medical University Innsbruck |
Lipidomics |
|
9:45-10:05 |
Elucidating plasmanyl and plasmenyl assignment in liquid chromatography and ion mobility separations, Jakob Koch, Medical University Innsbruck |
10:05-10:25 |
Unmasking double bond
positions in native complex lipids by streamlined processing of
chromatographic information in LC-MS/MS data, Leonida M. Lamp,
University of Graz |
10:25-10:45 |
Lipid metabolism in
Tuberous Sclerosis Complex disease, Florian Hatzmann, University of Innsbruck |
10:45-11:15 |
Coffee Break |
Award Session |
|
11:15-11:30 |
Quality Control in
Untargeted Metabolomics: Incorporating mzRAPP and Beyond, Yasin El Abiead, University of California |
11:30-11:45 |
Adipose Triglyceride
Lipase Loss Promotes a Metabolic Switch in A549 Non–Small Cell Lung Cance
Cell Spheroids, Sophie Honeder, Medical University Graz |
11:45-12:00 |
Mimicked synthetic
ribosomal protein complex for benchmarking crosslinking mass spectrometry
workflows, Manuel Matzinger, Institute of Molecular Pathology |
12:00-12:15 |
Cross-Validation in Lipidomics – towards a standardized and harmonized
omics
discipline, Harald Schoeny, University of Vienna |
12:15-13:00 |
Presentation
Awards and Closing Remarks |
Acknowledgements
Gold sponsors
Silver sponsors
Bronze sponsors
Organisation and Contact
Marcel Kwiatkowski – APRMS2023-conference@uibk.ac.at